Reelin signaling and cdk5 in the control of neuronal positioning

被引：34

作者：

Ohshima, T ^{[1
]}

Mikoshiba, K

机构：

[1] Inst Phys & Chem Res, Brain Sci Inst, Dev Neurobiol Lab, Wako, Saitama 35190198, Japan

[2] Univ Tokyo, Inst Med Sci, Dept Basic Med Sci, Div Mol Neurobiol,Minato Ku, Tokyo 1088639, Japan

来源：

MOLECULAR NEUROBIOLOGY | 2002年 / 26卷 / 2-3期

关键词：

Reelin; Dab1; CR-50; VLDLR; ApoER2; CNR; Cajal-Retzius cell; Cdk5; p35; p39;

D O I：

10.1385/MN:26:2-3:153

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuronal positioning is important for higher brain function because it is the architectural basis of the formation of precise synaptic circuits. Analysis of neurological mutant mice has led to dramatic progress in the identification and characterization of molecules important for neuronal positioning in the developing mammalian brain. Among these molecules, identification of signal pathways mediated by Reelin and Cdk5 kinase has provided a conceptual framework for exploring the molecular mechanisms underlying proper neuronal positioning in the developing mammalian brain. Recent evidence has implicated synergism between Reelin signaling and Cdk5 in contributing to the proper positioning of selective neuronal populations.

引用

页码：153 / 166

页数：14

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