Enantioselective organocatalysis

被引：529

作者：

Gaunt, Matthew J. ^{[1
]}

Johansson, Carin C. C. ^{[1
]}

McNally, Andy ^{[1
]}

Vo, Ngoc T. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

DRUG DISCOVERY TODAY | 2007年 / 12卷 / 1-2期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/j.drudis.2006.11.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Enantioselective organocatalysis has emerged as a powerful synthetic paradigm that is complementary to metal-catalysed transformations and has accelerated the development of new methods to make diverse chiral molecules. The operational simplicity, ready availability of catalysts and low toxicity associated with organocatalysis makes it an attractive method to synthesise complex structures. Here, we discuss the impact of enamine, iminium, nucleophilic and Bronsted acid catalysts in organic synthesis, and highlight key strategic methods to assemble useful molecules with high enantiomeric purity.

引用

页码：8 / 27

页数：20

共 116 条

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