Selective Expression of the Chemokine Receptor XCR1 on Cross-presenting Dendritic Cells Determines Cooperation with CD8+ T Cells

被引：357

作者：

Dorner, Brigitte G. ^{[1
]}

Dorner, Martin B. ^{[1
]}

Zhou, Xuefei ^{[1
]}

Opitz, Corinna ^{[1
]}

Mora, Ahmed ^{[1
]}

Guettler, Steffen ^{[1
]}

Hutloff, Andreas ^{[1
]}

Mages, Hans W. ^{[1
]}

Ranke, Katja ^{[1
]}

Schaefer, Michael ^{[2
]}

Jack, Robert S. ^{[3
]}

Henn, Volker ^{[1
]}

Kroczek, Richard A. ^{[1
]}

机构：

[1] Robert Koch Inst, D-13353 Berlin, Germany

[2] Rudolf Boehm Inst Pharmacol & Toxicol, D-04107 Leipzig, Germany

[3] Ernst Moritz Arndt Univ Greifswald, Inst Immunol, D-17489 Greifswald, Germany

来源：

IMMUNITY | 2009年 / 31卷 / 05期

关键词：

IN-VIVO; MOLECULAR-CLONING; BONE-MARROW; LYMPHOTACTIN; ANTIGENS; CYTOKINES; IMMUNITY; SUBSETS; DEC-205; CULTURE;

D O I：

10.1016/j.immuni.2009.08.027

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The expression of the chemokine receptor XCR1 and the function of its ligand XCL1 (otherwise referred to as ATAC, lymphotactin, or SCM-1) remained elusive to date. In the present report we demonstrated that XCR1 is exclusively expressed on murine CD8(+) dendritic cells (DCs) and showed that XCL1 is a potent and highly specific chemoattractant for this DC subset. CD8(+) T cells abundantly secreted XCL1 8-36 hr after antigen recognition on CD8(+) DCs in vivo, in a period in which stable T cell-DC interactions are known to occur. Functionally, XCL1 increased the pool of antigen-specific CD8(+) T cells and their capacity to secrete IFN-gamma. Absence of XCL1 impaired the development of cytotoxicity to antigens cross-presented by CD8(+) DCs. The XCL1 - XCR1 axis thus emerges as an integral component in the development of efficient cytotoxic immunity in vivo.

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收藏

页码：823 / 833

页数：11

相关论文

共 30 条

[1]

ORGANIZATION AND REORGANIZATION OF IMMUNOGLOBULIN GENES IN A-MULV TRANSFORMED-CELLS - REARRANGEMENT OF HEAVY BUT NOT LIGHT CHAIN GENES [J].

ALT, F ;

ROSENBERG, N ;

LEWIS, S ;

THOMAS, E ;

BALTIMORE, D .

CELL, 1981, 27 (02) :381-390

[2]

A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) [J].

Bleul, CC ;

Fuhlbrigge, RC ;

Casasnovas, JM ;

Aiuti, A ;

Springer, TA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) :1101-1109

[3]

Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance [J].

Bonifaz, L ;

Bonnyay, D ;

Mahnke, K ;

Rivera, M ;

Nussenzweig, MC ;

Steinman, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (12) :1627-1638

[4]

In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination [J].

Bonifaz, LC ;

Bonnyay, DP ;

Charalambous, A ;

Darguste, DI ;

Fujii, SI ;

Soares, H ;

Brimnes, MK ;

Moltedo, B ;

Moran, TM ;

Steinman, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (06) :815-824

[5]

CD8+ but not CD8- dendritic cells cross-prime cytotoxic T cells in vivo [J].

den Haan, JMM ;

Lehar, SM ;

Bevan, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (12) :1685-1695

[6]

Purification, structural analysis, and function of natural ATAC, a cytokine secreted by CD8(+) T cells [J].

Dorner, B ;

Muller, S ;

Entschladen, F ;

Schroder, JM ;

Frankel, P ;

Kraft, R ;

Friedl, P ;

ClarkLewis, I ;

Kroczek, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (13) :8817-8823

[7]

Coordinate expression of cytokines and chemokines by NK cells during murine cytomegalovirus infection [J].

Dorner, BG ;

Smith, HRC ;

French, AR ;

Kim, S ;

Poursine-Laurent, J ;

Beckman, DL ;

Pingel, JT ;

Kroczek, RA ;

Yokoyama, WM .

JOURNAL OF IMMUNOLOGY, 2004, 172 (05) :3119-3131

[8]

MIP-1α, MIP-1β, RANTES, and ATAC/lymphotactin function together with IFN-γ as type 1 cytokines [J].

Dorner, BG ;

Scheffold, A ;

Rolph, MS ;

Hüser, MB ;

Kaufmann, SHE ;

Radbruch, A ;

Flesch, IEA ;

Kroczek, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (09) :6181-6186

[9]

Dendritic cell immunotherapy: mapping the way [J].

Figdor, CG ;

de Vries, IJM ;

Lesterhuis, WJ ;

Melief, CJM .

NATURE MEDICINE, 2004, 10 (05) :475-480

[10]

Making friends in out-of-the-way places:: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging [J].

Germain, Ronald N. ;

Bajenoff, Marc ;

Castellino, Flora ;

Chieppa, Marcello ;

Egen, Jackson G. ;

Huang, Alex Y. C. ;

Ishii, Masaru ;

Koo, Lily Y. ;

Qi, Hai .

IMMUNOLOGICAL REVIEWS, 2008, 221 :163-181