Creatine monohydrate in muscular dystrophies:: A double-blind, placebo-controlled clinical study

被引：117

作者：

Walter, MC

Lochmüller, H

Reilich, P

Klopstock, T

Huber, R

Hartard, M

Hennig, M

Pongratz, D

Müller-Felber, W

机构：

[1] Univ Munich, Med Klin, Friedrich Baur Inst, D-80336 Munich, Germany

[2] Univ Munich, Dept Neurol, D-80336 Munich, Germany

[3] Univ Munich, Dept Pulmonol, D-80336 Munich, Germany

[4] Tech Univ Munich, Dept Sports Med, D-8000 Munich, Germany

[5] Tech Univ Munich, Inst Med Stat & Epidemiol, D-8000 Munich, Germany

来源：

NEUROLOGY | 2000年 / 54卷 / 09期

关键词：

creatine; therapy; muscular dystrophy; dietary supplement;

D O I：

10.1212/WNL.54.9.1848

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors assessed the safety and efficacy of creatine monohydrate (Cr) in various types of muscular dystrophies in a double-blind, crossover trial. Thirty-six patients (12 patients with facioscapulohumeral dystrophy, 10 patients with Becker dystrophy, 8 patients with Duchenne dystrophy, and 6 patients with sarcoglycan-deficient limb girdle muscular dystrophy) were randomized to receive Cr or placebo for 8 weeks. There was mild but significant improvement in muscle strength and daily-life activities by Medical Research Council scales and the Neuromuscular Symptom Score. Cr was well tolerated throughout the study period.

引用

页码：1848 / 1850

页数：3