Dietary flavonoids: Nano delivery and nanoparticles for cancer therapy

被引：89

作者：

Aiello, Paola ^{[1
,2
,3
]}

Consalvi, Sara ^{[4
]}

Poce, Giovanna ^{[4
]}

Raguzzini, Anna ^{[1
]}

Toti, Elisabetta ^{[1
]}

Palmery, Maura ^{[2
]}

Biava, Mariangela ^{[4
]}

Bernardi, Marco ^{[2
]}

Kamal, Mohammad A. ^{[5
,6
,7
]}

Perry, George ^{[8
]}

Peluso, Ilaria ^{[1
]}

机构：

[1] Council Agr Res & Econ CREA AN, Res Ctr Food & Nutr, Via Ardeatina 546, Rome, Italy

[2] Sapienza Univ Rome, Dept Physiol & Pharmacol V Erspamer, Rome, Italy

[3] Univ Catolica San Antonio Murcia UCAM, Murcia, Spain

[4] Univ Roma La Sapienza, Dept Chem & Drug Technol, Rome, Italy

[5] King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah, Saudi Arabia

[6] Enzymoics, 7 Peterlee Pl, Hebersham, NSW 2770, Australia

[7] Novel Global Community Educ Fdn, Sydney, NSW, Australia

[8] Univ Texas San Antonio, Dept Biol, San Antonio, TX 78249 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2021年 / 69卷

关键词：

Epigallocatechin gallate; Quercetin; Flavonoids; Cancer; Nanoparticle; MAJOR FOOD SOURCES; MESOPOROUS SILICA NANOPARTICLES; LOADED CHITOSAN NANOPARTICLES; NANOSTRUCTURED LIPID CARRIERS; 1000 SUCCINATE NANOPARTICLES; TEA CATECHIN DERIVATIVES; IN-VITRO; GREEN TEA; BREAST-CANCER; GOLD NANOPARTICLES;

D O I：

10.1016/j.semcancer.2019.08.029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Application of nanotechnologies to cancer therapy might increase solubility and/or bioavailability of bioactive compounds of natural or synthetic origin and offers other potential benefits in cancer therapy, including selective targeting. In the present review we aim to evaluate in vivo studies on the anticancer activity of nanoparticles (NPs) obtained from food-derived flavonoids. From a systematic search a total of 60 studies were identified. Most of the studies involved the flavanol epigallocatechin-3-O-gallate and the flavonol quercetin, in both delivery and co-delivery (with anti-cancer drugs) systems. Moreover, some studies investigated the effects of other flavonoids, such as anthocyanins aglycones anthocyanidins, flavanones, flavones and isoflavonoids. NPs inhibited tumor growth in both xenograft and chemical-induced animal models of cancerogenesis.

引用

页码：150 / 165

页数：16

共 167 条

[1]

Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo [J].

Abdelhalim, Mohamed Anwar K. ;

Qaid, Huda A. Y. ;

Al-Mohy, Yanallah ;

Al-Ayed, Mohammed Suliman .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2018, 13 :7765-7770

[2]

Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines [J].

Aghapour, Fahimeh ;

Moghadamnia, Ali Akbar ;

Nicolini, Andrea ;

Kani, Seydeh Narges Mousavi ;

Barari, Ladan ;

Morakabati, Payam ;

Rezazadeh, Leyla ;

Kazemi, Sohrab .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 500 (04) :860-865

[3]

Targeting Cancer with Nano-Bullets: Curcumin, EGCG, Resveratrol and Quercetin on Flying Carpets [J].

Aras, Aliye ;

Khokhar, Abdur Rehman ;

Qureshi, Muhammad Zahid ;

Silva, Marcela Fernandes ;

Sobczak-Kupiec, Agnieszka ;

Gomez Pineda, Edgardo Alfonso ;

Winkler Hechenleitner, Ana Adelina ;

Farooqi, Ammad Ahmad .

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (09) :3865-3871

[4]

Hyaluronic acid-green tea catechin micellar nanocomplexes: Fail-safe cisplatin nanomedicine for the treatment of ovarian cancer without off-target toxicity [J].

Bae, Ki Hyun ;

Tan, Susi ;

Yamashita, Atsushi ;

Ang, Wei Xia ;

Gao, Shu Jun ;

Wang, Shu ;

Chung, Joo Eun ;

Kurisawa, Motoichi .

BIOMATERIALS, 2017, 148 :41-53

[5]

Intakes of total and individual flavonoids by US adults [J].

Bai, Wei ;

Wang, Chunyang ;

Ren, Cuirong .

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2014, 65 (01) :9-20

[6]

In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles [J].

Baksi, Ruma ;

Singh, Devendra Pratap ;

Borse, Swapnil P. ;

Rana, Rita ;

Sharma, Vipin ;

Nivsarkar, Manish .

BIOMEDICINE & PHARMACOTHERAPY, 2018, 106 :1513-1526

[7]

Gold nanoparticle-conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2-mediated pathway in breast cancer [J].

Balakrishnan, S. ;

Bhat, F. A. ;

Raja Singh, P. ;

Mukherjee, S. ;

Elumalai, P. ;

Das, S. ;

Patra, C. R. ;

Arunakaran, J. .

CELL PROLIFERATION, 2016, 49 (06) :678-697

[8]

Gold nanoparticles-conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt-mediated pathway in breast cancer cell lines (MCF-7 and MDA-MB-231) [J].

Balakrishnan, Solaimuthu ;

Mukherjee, Sudip ;

Das, Sourav ;

Bhat, Firdous Ahmad ;

Singh, Paulraj Raja ;

Patra, Chitta Ranjan ;

Arunakaran, Jagadeesan .

CELL BIOCHEMISTRY AND FUNCTION, 2017, 35 (04) :217-231

[9]

Toxicological effects of Camellia sinensis (green tea): A review [J].

Bedrood, Zeinab ;

Rameshrad, Maryam ;

Hosseinzadeh, Hossein .

PHYTOTHERAPY RESEARCH, 2018, 32 (07) :1163-1180

[10]

Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats [J].

Bhattacharya, Sanchari ;

Mondal, Laboni ;

Mukherjee, Biswajit ;

Dutta, Lopamudra ;

Ehsan, Iman ;

Debnath, Mita C. ;

Gaonkar, Raghuvir H. ;

Pal, Murari M. ;

Majumdar, Subrata .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2018, 14 (06) :1905-1917

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