Prolonged intestinal afferent nerve discharge in response to cholecystokinin-58 compared to cholecystokinin-8 in rats

被引:25
作者
Kreis, ME
Zittel, TT
Raybould, HE
Reeve, JR
Grundy, D
机构
[1] UNIV TUBINGEN HOSP,DEPT GEN SURG,TUBINGEN,GERMANY
[2] UNIV CALIF LOS ANGELES,CTR ULCER RES & EDUC,GASTROENTER BIOL CTR,LOS ANGELES,CA 90024
[3] UNIV SHEFFIELD,DEPT BIOMED SCI,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND
关键词
afferent nerve; cholecystokinin-8; cholecystokinin-58; cholecystokinin physiology; extrinsic innervation; small intestine;
D O I
10.1016/S0304-3940(97)00483-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Intestinal afferents are sensitive to cholecystokinin (CCK) octapeptide. However, CCK-58 may be a more biologically relevant molecule. Therefore, recordings from jejunal mesenteric afferent bundles were secured for extracellular multi-unit recording and the responses to CCK-8 and CCK-58 compared. CCK-8 and CCK-58 (i.v.) evoked a dose-dependent, devazepide sensitive, increase in afferent nerve discharge, Peak discharge frequency was higher for CCK-8 at all doses (P < 0.05). However, response duration was more prolonged for CCK-58 (P < 0.05) at 200 pmol.kg(-1). This resulted in an overall increase in area under the curve of CCK-58 compared to CCK-8 (P < 0.05). CCK-58 stimulates afferent discharge in a different pattern than CCK-8 and, therefore, may have differential biological effects. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:89 / 92
页数:4
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