Interleukin-15 and the regulation of lymphoid homeostasis

被引：65

作者：

Lodolce, J

Burkett, P

Koka, R

Boone, D

Chien, M

Chan, F

Madonia, M

Chai, S

Ma, A

机构：

[1] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[2] Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA

来源：

MOLECULAR IMMUNOLOGY | 2002年 / 39卷 / 09期

关键词：

interleukin-15; lymphoid homeostasis; pleiotropic expression;

D O I：

10.1016/S0161-5890(02)00211-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-15 (IL-15) is a cytokine that plays unique roles in both innate and adaptive immune cell homeostasis. While early studies suggested that IL-15 resembled IL-2, more recent work suggests that IL-15 may play multiple unique roles in immune homeostasis befitting its pleiotropic expression pattern. This review will focus on recent studies that highlight some of these functions. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：537 / 544

页数：8

共 70 条

[41]

2-A

[42] Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response [J].