Chromosome-encoded ambler class A β-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum β-lactamases

被引：201

作者：

Poirel, L

Kämpfer, P

Nordmann, P

机构：

[1] Hop Bicetre, Fac Med Paris Sud, Assistance Publ Hop Paris, Serv Bacteriol Virol, F-94275 Le Kremlin Bicetre, France

[2] Univ Giessen, Inst Angew Mikrobiol, D-35392 Giessen, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 12期

关键词：

D O I：

10.1128/AAC.46.12.4038-4040.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A chromosome-encoded P-lactamase gene, cloned and expressed in Escherichia coli from Kluyvera georgiana reference strain CUETM 4246-74 (DSM 9408), encoded the extended-spectrum beta-lactamase KLUG-1, which shared 99% amino acid identity with the plasmid-mediated P-lactamase CTX-M-8. This work provides further evidence that Kluyvera spp. may be the progenitor(s) of CTX-M-type beta-lactamases.

引用

页码：4038 / 4040

页数：3

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