Transport between ER and Golgi

被引:103
作者
Klumperman, J
机构
[1] Univ Utrecht, Med Ctr, Inst Biomembranes, Dept Cell Biol, NL-3584 CX Utrecht, Netherlands
[2] Univ Utrecht, Med Ctr, Ctr Biomed Genet, NL-3584 CX Utrecht, Netherlands
关键词
D O I
10.1016/S0955-0674(00)00115-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In the last eighteen months, it has become clear that some classes of proteins are actively recruited into endoplasmic reticulum export carriers, whereas others are exported as bulkflow cargo. Subsequent transport to the Golgi is mediated by tubulovesicular membranes. The anterograde membrane flow is compensated for by a retrograde pathway, which, in addition to the recycling of membrane and proteins to the endoplasmic reticulum, may play a role in anterograde cargo concentration.
引用
收藏
页码:445 / 449
页数:5
相关论文
共 53 条
  • [21] Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs
    Hay, JC
    Klumperman, J
    Oorschot, V
    Steegmaier, M
    Kuo, CS
    Scheller, RH
    [J]. JOURNAL OF CELL BIOLOGY, 1998, 141 (07) : 1489 - 1502
  • [22] Transport from the endoplasmic reticulum to the Golgi
    Kaiser, C
    Ferro-Novick, S
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (04) : 477 - 482
  • [23] Kelly RB, 1999, TRENDS CELL BIOL, V9, pM29, DOI 10.1016/S0962-8924(99)01687-6
  • [24] Klumperman J, 1998, J CELL SCI, V111, P3411
  • [25] COPII-cargo interactions direct protein sorting into ER-derived transport vesicles
    Kuehn, MJ
    Herrmann, JM
    Schekman, R
    [J]. NATURE, 1998, 391 (6663) : 187 - 190
  • [26] Roles for α2p24 and COPI in endoplasmic reticulum cargo exit site formation
    Lavoie, C
    Paiement, J
    Dominguez, M
    Roy, L
    Dahan, S
    Gushue, JN
    Bergeron, JJM
    [J]. JOURNAL OF CELL BIOLOGY, 1999, 146 (02) : 285 - 299
  • [27] IMMUNOCYTOCHEMICAL ANALYSIS OF THE TRANSFER OF VESICULAR STOMATITIS VIRUS-G GLYCOPROTEIN FROM THE INTERMEDIATE COMPARTMENT TO THE GOLGI-COMPLEX
    LOTTI, LV
    TORRISI, MR
    PASCALE, MC
    BONATTI, S
    [J]. JOURNAL OF CELL BIOLOGY, 1992, 118 (01) : 43 - 50
  • [28] Vesicular tubular clusters between the ER and Golgi mediate concentration of soluble secretory proteins by exclusion front COPI-coated vesicles
    Martínez-Menárguez, JA
    Geuze, HJ
    Slot, JW
    Klumperman, J
    [J]. CELL, 1999, 98 (01) : 81 - 90
  • [29] THE GOLGI-COMPLEX - INVITRO VERITAS
    MELLMAN, I
    SIMONS, K
    [J]. CELL, 1992, 68 (05) : 829 - 840
  • [30] A SOLUBLE SECRETORY PROTEIN IS 1ST CONCENTRATED IN THE ENDOPLASMIC-RETICULUM BEFORE TRANSFER TO THE GOLGI-APPARATUS
    MIZUNO, M
    SINGER, SJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (12) : 5732 - 5736