Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae)

被引:94
作者
Saludes, JP
Garson, MJ
Franzblau, SG
Aguinaldo, AM [1 ]
机构
[1] Univ Santo Tomas, Res Ctr Nat Sci, Manila 1008, Philippines
[2] Univ Queensland, Dept Chem, Brisbane, Qld 4072, Australia
[3] Natl Dis Ctr, Baton Rouge, LA USA
关键词
Morinda citrifolia; antitubercular activity; epidioxysterols; ketosteroids; phytol;
D O I
10.1002/ptr.1003
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A crude ethanol extract and hexane fraction from Morinda citrifolia Linn. (Rubiaceae) show antitubercular activity. The major constituents of the hexane fraction are E-phytol, cycloartenol, stigmasterol, beta-sitosterol, campesta-5,7,22-trien-3beta-ol and the ketosteroids stigmasta-4-en-3-one and stigmasta-4-22-dien-3-one. E-Phytol, a mixture of the two ketosteroids, and the epidioxysterol derived from campesta-5,7,22-trien-3beta-ol all show pronounced antitubercular activity. Copyright (C) 2002 John Wiley Sons, Ltd.
引用
收藏
页码:683 / 685
页数:3
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