Immunogenicity of hepatitis B vaccines: implications of immune memory

被引：49

作者：

Koff, RS ^{[1
]}

机构：

[1] Univ Massachusetts, Mem Med Ctr, Div Gastroenterol, Dept Med, Worcester, MA 01655 USA

来源：

VACCINE | 2002年 / 20卷 / 31-32期

关键词：

hepatitis B; vaccination; immunogenicity;

D O I：

10.1016/S0264-410X(02)00405-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The subunit recombinant hepatitis B virus (HBV) vaccines available in the US differ in hepatitis B surface antigen content. Clinical studies have linked higher antigen formulations with enhanced peak protective antibody levels. This is important for the elderly, smokers, the obese, and the immunocompromised. Immune memory, which is responsible for prolonged protection when HBV vaccine-induced antibody levels become undetectable, may be related to antigen persistence on immunologically active cells. Antigen persistence may be related to antigen content of the vaccine and thereby influences the duration of immunity. Proof of this concept will require additional studies of immune memory in HBV. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3695 / 3701

页数：7

共 38 条

[21] Long-term efficacy of plasma-derived hepatitis B vaccine: a 15-year follow-up study among Chinese children [J].

Liao, SS ;

Li, RC ;

Li, H ;

Yang, JY ;

Zeng, XJ ;

Gong, J ;

Wang, SS ;

Li, YP ;

Zhang, KL .

VACCINE, 1999, 17 (20-21) :2661-2666

[22] PREVENTION OF HEPATITIS-B VIRUS TRANSMISSION BY IMMUNIZATION - AN ECONOMIC-ANALYSIS OF CURRENT RECOMMENDATIONS [J].

MARGOLIS, HS ;

COLEMAN, PJ ;

BROWN, RE ;

MAST, EE ;

SHEINGOLD, SH ;

AREVALO, JA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (15) :1201-1208

[23] Prevalence of hepatitis B virus infection in the United States: The National Health and Nutrition Examination Surveys, 1976 through 1994 [J].

McQuillan, GM ;

Coleman, PJ ;

Kruszon-Moran, D ;

Moyer, LA ;

Lambert, SB ;

Margolis, HS .

AMERICAN JOURNAL OF PUBLIC HEALTH, 1999, 89 (01) :14-18

[24] Intradermal recombinant hepatitis B vaccine for healthcare workers who fail to respond to intramuscular vaccine [J].

Playford, EG ;

Hogan, PG ;

Bansal, AS ;

Harrison, K ;

Drummond, D ;

Looke, DFM ;

Whitby, M .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2002, 23 (02) :87-90

[25]

Poland GA, 1998, AM J PREV MED, V15, P73

[26] Cellular and humoral immune responses induced by intradermal or intramuscular vaccination with the major hepatitis B surface antigen [J].

Rahman, F ;

Dahmen, A ;

Herzog-Hauff, S ;

Böcher, WO ;

Galle, PR ;

Löhr, HF .

HEPATOLOGY, 2000, 31 (02) :521-527

[27] Antibody-response to three recombinant hepatitis B vaccines: comparative evaluation of multicenter travel-clinic based experience [J].

Rendi-Wagner, P ;

Kundi, M ;

Stemberger, H ;

Wiedermann, G ;

Holzmann, H ;

Hofer, M ;

Wiesinger, K ;

Kollaritsch, H .

VACCINE, 2001, 19 (15-16) :2055-2060

[28] COMPARATIVE-STUDY OF THE IMMUNOGENICITY AND SAFETY OF 2 DOSES OF RECOMBINANT HEPATITIS-B VACCINE IN HEALTHY ADOLESCENTS [J].

SCHIFF, GM ;

SHERWOOD, JR ;

ZELDIS, JB ;

KRAUSE, DS .

JOURNAL OF ADOLESCENT HEALTH, 1995, 16 (01) :12-17

[29]

*SMITHKL BEECH PHA, 2001, PRESCR INF TWINR

[30] The first combined vaccine against hepatitis A and B: an overview [J].

Thoelen, S ;

Van Damme, P ;

Leentvaar-Kuypers, A ;

Leroux-Roels, G ;

Bruguera, M ;

Frei, PC ;

Bakasenas, V ;

Safary, A .

VACCINE, 1999, 17 (13-14) :1657-1662

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