A microfluidic system for controlling reaction networks in time

被引:1030
作者
Song, H [1 ]
Tice, JD [1 ]
Ismagilov, RF [1 ]
机构
[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA
关键词
analytical methods; kinetics; microfluidics; microreactors; reaction networks;
D O I
10.1002/anie.200390203
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Millisecond mixing and transport with no dispersion are achieved by unsteady flows induced in droplets of about 60 pL that travel through winding microfluidic channels (top). Fluorescence can be used to monitor mixing (bottom) or measure reaction rates. In principle, arbitrarily complex reaction networks can be created by combining and splitting streams of such droplets.
引用
收藏
页码:768 / 772
页数:5
相关论文
共 33 条
  • [21] Ottino J. M., 1989, KINEMATICS MIXING ST
  • [22] Micro total analysis systems. 1. Introduction, theory, and technology
    Reyes, DR
    Iossifidis, D
    Auroux, PA
    Manz, A
    [J]. ANALYTICAL CHEMISTRY, 2002, 74 (12) : 2623 - 2636
  • [23] A continuous-flow capillary mixing method to monitor reactions on the microsecond time scale
    Shastry, MCR
    Luck, SD
    Roder, H
    [J]. BIOPHYSICAL JOURNAL, 1998, 74 (05) : 2714 - 2721
  • [24] HYDRODYNAMIC CHROMATOGRAPHY
    SMALL, H
    LANGHORST, MA
    [J]. ANALYTICAL CHEMISTRY, 1982, 54 (08) : A892 - &
  • [25] CHAOTIC PARTICLE-TRANSPORT IN TIME-DEPENDENT RAYLEIGH-BENARD CONVECTION
    SOLOMON, TH
    GOLLUB, JP
    [J]. PHYSICAL REVIEW A, 1988, 38 (12): : 6280 - 6286
  • [26] Artificial blood
    Squires, JE
    [J]. SCIENCE, 2002, 295 (5557) : 1002 - +
  • [27] Chaotic mixer for microchannels
    Stroock, AD
    Dertinger, SKW
    Ajdari, A
    Mezic, I
    Stone, HA
    Whitesides, GM
    [J]. SCIENCE, 2002, 295 (5555) : 647 - 651
  • [28] Effect of channel structure on microchannel emulsification
    Sugiura, S
    Nakajima, M
    Seki, M
    [J]. LANGMUIR, 2002, 18 (15) : 5708 - 5712
  • [29] Dynamic pattern formation in a vesicle-generating microfluidic device
    Thorsen, T
    Roberts, RW
    Arnold, FH
    Quake, SR
    [J]. PHYSICAL REVIEW LETTERS, 2001, 86 (18) : 4163 - 4166
  • [30] Microfluidic large-scale integration
    Thorsen, T
    Maerkl, SJ
    Quake, SR
    [J]. SCIENCE, 2002, 298 (5593) : 580 - 584