A cellular mechanism for the bidirectional pain-modulating actions of orphanin FQ/nociceptin

被引：129

作者：

Pan, ZZ ^{[1
]}

Hirakawa, N

Fields, HL

机构：

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, WM Keck Ctr Integrat Neurosci, San Francisco, CA 94143 USA

来源：

NEURON | 2000年 / 26卷 / 02期

关键词：

D O I：

10.1016/S0896-6273(00)81183-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Orphanin FQ/nociceptin (OFQ/N) and its receptor share substantial structural features and cellular actions with classic opioid peptides and receptors, but have distinct pharmacological profiles and behavioral effects. Currently there is an active debate about whether OFQ/N produces hyperalgesia or analgesia. Using a well-defined brainstem pain-modulating circuit, we show that OFQ/N can cause either an apparent hyperalgesia by antagonizing mu opioid-induced analgesia or a net analgesic effect by reducing the hyperalgesia during opioid abstinence. It presumably produces these two opposite actions by inhibiting two distinct groups of neurons whose activation mediates the two effects of opioid administration. OFQ/N antagonism of the hyperalgesia may have significance for the treatment of opioid withdrawal and sensitized pain.

引用

页码：515 / 522

页数：8

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