Rapid combined T1 and T2 mapping using gradient recalled acquisition in the steady state

A novel, fully 3D, high-resolution T-1 and T-2 relaxation time mapping method is presented. The method is based on steadystate imaging with T-1 and T-2 information derived from either spoiling or fully refocusing the transverse magnetization following each excitation pulse. T-1 is extracted from a pair of spoiled gradient recalled echo (SPGR) images acquired at optimized flip angles. This T-1 information is combined with two refocused steady-state free precession (SSFP) images to determine T-2. T-1 and T-2 accuracy was evaluated against inversion recovery (IR) and spin-echo (SE) results, respectively. Error within the T-1 and T-2 maps, determined from both phantom and in vivo measurements, is approximately 7% for T-1 between 300 and 2000 ms(.) and 7% for T-2 between 30 and 150 ms. The efficiency of the method, defined as the signal-to-noise ratio (SNR) of the final map per voxel volume per square root scan time, was evaluated against alternative mapping methods. With an efficiency of three times that of multipoint IR and three times that of multi-echo SE, our combined approach represents the most efficient of those examined. Acquisition time for a whole brain T-1 map (25 x 25 x 10 cm) is less than 8 min with 1 mm(3) isotropic voxels. An additional 7 min is required for an identically sized T-2 map and postprocessing time is less than 1 min on a 1 GHz Pill PC. The method therefore permits real-time clinical acquisition and display of whole brain T-1 and T-2 maps for the first time. (C) 2003 Wiley-Liss, Inc.