The surgical treatment of Parkinson's disease

被引:20
作者
Follett, KA [1 ]
机构
[1] Univ Iowa Hosp & Clin, Div Neurosurg, Iowa City, IA 52242 USA
来源
ANNUAL REVIEW OF MEDICINE | 2000年 / 51卷
关键词
movement disorder; thalamotomy; pallidotomy; deep brain stimulation;
D O I
10.1146/annurev.med.51.1.135
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Surgical treatment of Parkinson's disease (PD) can provide gratifying symptomatic improvements for many individuals who suffer from persistent disabling symptoms despite the best available medical management. Current surgical therapies include ablative techniques (thalamotomy and pallidotomy), augmentative techniques (nondestructive) (deep brain stimulation), and restorative techniques (tissue transplantation and gene therapy). Ablative procedures can provide substantial clinical benefit, but the current trend is toward deep brain stimulation, which can provide similar symptomatic improvement in a nondestructive manner. Restorative techniques, such as tissue transplantation and gene therapy, are exciting but have significant obstacles to overcome before their promise can be realized. Until the underlying pathological defect of PD can be identified and treated, surgical intervention is Likely to remain important in the symptomatic treatment of this disabling disease.
引用
收藏
页码:135 / 147
页数:13
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