GPCRdb: an information system for G protein-coupled receptors

被引：228

作者：

Isberg, Vignir ^{[1
]}

Mordalski, Stefan ^{[2
]}

Munk, Christian ^{[1
]}

Rataj, Krzysztof ^{[2
]}

Harpsoe, Kasper ^{[1
]}

Hauser, Alexander S. ^{[1
]}

Vroling, Bas ^{[3
]}

Bojarski, Andrzej J. ^{[2
]}

Vriend, Gert ^{[4
]}

Gloriam, David E. ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Drug Design & Pharmacol, Jagtvej 162, DK-2100 Copenhagen, Denmark

[2] Polish Acad Sci, Inst Pharmacol, Dept Med Chem, Smetna 12, PL-31343 Krakow, Poland

[3] Bioprodict BV, Nieuwe Markstr 54E, NL-6511 AA Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, CMBI, NCMLS, Med Ctr, Geert Grootepl Zuid 26-28, NL-6525 GA Nijmegen, Netherlands

来源：

NUCLEIC ACIDS RESEARCH | 2016年 / 44卷 / D1期

基金：

欧洲研究理事会;

关键词：

CRYSTAL-STRUCTURE; ALLOSTERIC MODULATION; OPIOID RECEPTOR; DATABASE; FAMILY; ACTIVATION; LIGANDS; DOCKING;

D O I：

10.1093/nar/gkv1178

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific foundation for drug design studies. The GPCR database, GPCRdb, serves a dual role in disseminating and enabling new scientific developments by providing reference data, analysis tools and interactive diagrams. This paper highlights new features in the fifth major GPCRdb release: (i) GPCR crystal structure browsing, superposition and display of ligand interactions; (ii) direct deposition by users of point mutations and their effects on ligand binding; (iii) refined snake and helix box residue diagram looks; and (iii) phylogenetic trees with receptor classification colour schemes. Under the hood, the entire GPCRdb front-and back-ends have been recoded within one infrastructure, ensuring a smooth browsing experience and development. GPCRdb is available at http://www.gpcrdb.org/ and it's open source code at https://bitbucket.org/gpcr/protwis.

引用

页码：D356 / D364

页数：9

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