Autophagy in cardiovascular health and disease

被引：42

作者：

Abdellatif, Mahmoud ^{[1
]}

Ljubojevic-Holzer, Senka ^{[1
,2
]}

Madeo, Frank ^{[2
,3
]}

Sedej, Simon ^{[1
,2
,4
]}

机构：

[1] Med Univ Graz, Dept Cardiol, Graz, Austria

[2] BioTechMed Graz, Graz, Austria

[3] Karl Franzens Univ Graz, NAWI Graz, Inst Mol Biosci, Graz, Austria

[4] Univ Maribor, Fac Med, Inst Physiol, Maribor, Slovenia

来源：

AUTOPHAGY IN HEALTH AND DISEASE | 2020年 / 172卷

基金：

奥地利科学基金会;

关键词：

TERM CALORIC RESTRICTION; DOXORUBICIN CARDIOTOXICITY; MITOCHONDRIAL DYSFUNCTION; CONTRACTILE FUNCTION; CARDIOMYOCYTE DEATH; CARDIAC AUTOPHAGY; OXIDATIVE STRESS; NITRIC-OXIDE; LIFE-SPAN; REPERFUSION;

D O I：

10.1016/bs.pmbts.2020.04.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Autophagy is a cellular housekeeping and quality control mechanism that is essential for homeostasis and survival. By virtue of this role, any perturbations to the flow of this process in cardiac or vascular cells can elicit harmful effects on the cardiovascular system, and subsequently affect whole organismal health. In this chapter, we summarize the preclinical evidence supporting the role of autophagy in sustaining cardiovascular health during homeostasis and disease. Furthermore, we discuss how autophagy activation by dietary, genetic and pharmaceutical interventions can be exploited to counteract common cardiovascular disorders, including atherosclerosis, coronary artery disease, diabetic cardiomyopathy, arrhythmia, chemotherapy-induced cardiotoxicity and heart failure.

引用

收藏

页码：87 / 106

页数：20

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