[1] Univ Oulu, Fac Med, Inst Clin Med, Computat Med Res Grp, Oulu, Finland
[2] Univ Oulu, Bioctr, Oulu, Finland
[3] Univ Kuopio, Dept Biosci, Chem Lab, NMR Metabon Lab, FIN-70211 Kuopio, Finland
[4] Univ Oulu, Dept Internal Med, Clin Res Ctr, SF-90220 Oulu, Finland