Magnetic fluid hyperthermia of the mouse experimental tumor

被引：62

作者：

Brusentsov, NA ^{[1
]}

Nikitin, LV

Brusentsova, TN

Kuznetsov, AA

Bayburtskiy, FS

Shumakov, LI

Jurchenko, NY

机构：

[1] Russian Acad Med Sci, Blokhin Oncol Res Ctr, Moscow 115478, Russia

[2] Moscow MV Lomonosov State Univ, Moscow 119899, Russia

[3] Moscow MV Lomonosov State Univ, Inst Mech, Moscow 117192, Russia

[4] Russian Acad Sci, Inst Biochem Phys, Moscow 117977, Russia

[5] Mendeleev Univ Chem Technol, Moscow 125047, Russia

[6] Russian Radiotech Res Inst, Moscow, Russia

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2002年 / 252卷 / 1-3期

关键词：

sarcoma; magnetic fluid hyperthermia; dextran-ferrite targeting-inhomogeneous permanent magnetic field (PMF); AC magnetic field-water-filtered;

D O I：

10.1016/S0304-8853(02)00634-0

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Four of the water-based dextran-ferrite (DF) magnetic fluids (MF) were prepared. Their saturation magnetization was from 0.9 to 7.5 kA/m; specific power absorption rates were 210 W/g Fe; pH was from 6 to 9 and Zeta-potential (zeta) was from + 18 to -12 mV. After nine magnetic fluid tumor hyperthermia at + 44degreesC to + 45degreesC, 30 min with water-filtered AC magnetic field (0.88 MHz, 9.3 kA/m, 0.15 kW), while using DF MF (saturation magnetization 7.5 kA/m, pH 6.6, zeta + 15 mV), a complete tumor regression sarcoma MX11 in C57B1/6j mice was 33%, life span increase achieved was 150%. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：378 / 380

页数：3

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