Asymmetric Organocatalytic Relay Cascades: Catalyst-Controlled Stereoisomer Selection in the Synthesis of Functionalized Cyclohexanes

被引:128
作者
Wang, Yao [1 ]
Han, Rong-Gang [1 ]
Zhao, Yong-Long [1 ]
Yang, Shu [1 ]
Xu, Peng-Fei [1 ]
Dixon, Darren J. [2 ]
机构
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
基金
英国工程与自然科学研究理事会;
关键词
cascade reactions; diastereomers; enantioselectivity; organocatalysis; relay catalysis; MEDIATED ENANTIOSELECTIVE CONSTRUCTION; DOMINO MICHAEL-ALDOL; ALPHA; BETA-UNSATURATED ALDEHYDES; BIFUNCTIONAL CATALYSIS; CONJUGATE ADDITION; FORMAL SYNTHESIS; STEREOCENTERS; DERIVATIVES; MALONATE; METAL;
D O I
10.1002/anie.200905014
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(figure represented) Passing the baton: A relay cascade process provides cyclohexanes in a direct, efficient, and stereoselective manner. The triple-cascade reaction is efficient, affords high selectivities, and has a broad scope, and different diastereomers are readily accessible by judicious choice of organocatalysts. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:9834 / 9838
页数:5
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