Asymmetric Organocatalytic Relay Cascades: Catalyst-Controlled Stereoisomer Selection in the Synthesis of Functionalized Cyclohexanes

被引：128

作者：

Wang, Yao ^{[1
]}

Han, Rong-Gang ^{[1
]}

Zhao, Yong-Long ^{[1
]}

Yang, Shu ^{[1
]}

Xu, Peng-Fei ^{[1
]}

Dixon, Darren J. ^{[2
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 52期

基金：

英国工程与自然科学研究理事会;

关键词：

cascade reactions; diastereomers; enantioselectivity; organocatalysis; relay catalysis; MEDIATED ENANTIOSELECTIVE CONSTRUCTION; DOMINO MICHAEL-ALDOL; ALPHA; BETA-UNSATURATED ALDEHYDES; BIFUNCTIONAL CATALYSIS; CONJUGATE ADDITION; FORMAL SYNTHESIS; STEREOCENTERS; DERIVATIVES; MALONATE; METAL;

D O I：

10.1002/anie.200905014

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(figure represented) Passing the baton: A relay cascade process provides cyclohexanes in a direct, efficient, and stereoselective manner. The triple-cascade reaction is efficient, affords high selectivities, and has a broad scope, and different diastereomers are readily accessible by judicious choice of organocatalysts. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9834 / 9838

页数：5

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