Palladium-catalyzed methylation and arylation of sp2 and sp3 C-H bonds in simple carboxylic acids

被引：653

作者：

Giri, Ramesh ^{[1
]}

Maugel, Nathan ^{[1
]}

Li, Jiao-Jie ^{[1
]}

Wang, Dong-Hui ^{[1
]}

Breazzano, Steven P. ^{[1
]}

Saunders, Lindsey B. ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem MS015, Waltham, MA 02454 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 12期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1021/ja0701614

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of preformed sodium carboxylates as substrates led to the first observation of facile Pd-insertions into sp(3) beta-C-H bonds in simple aliphatic acids. Consequently, Pd-catalyzed methylation and arylation of o-C-H bonds in benzoic acids and beta-C-H bonds in aliphatic acids using either a phenylboronate, methylboronic acid, or ArI have been achieved via a C-H activation/C-C coupling sequence.

引用

页码：3510 / +

页数：3

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