Chemoselective inhibition of the hydrogenolysis of the MPM protective group for phenolic hydroxy functions using a Pd/C-pyridine catalyst

被引:49
作者
Sajiki, H [1 ]
Kuno, H [1 ]
Hirota, K [1 ]
机构
[1] GIFU PHARMACEUT UNIV,MED CHEM LAB,GIFU 502,JAPAN
关键词
D O I
10.1016/S0040-4039(96)02309-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A convenient method for the selective hydrogenation of phenolic benzyl ether, Cbz, benzyl ester, nitro and olefin functions distinguishing from the MPM (4-methoxybenzyl) protective group for the phenolic hydroxy groups was accomplished by the addition of pyridine to the Pd/C-catalyzed reduction system. Copyright (C) 1996 Elsevier Science Ltd
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页码:399 / 402
页数:4
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