A 41-kDa antigen of the rodent filaria Acanthocheilonema viteae with homologies to tropomyosin induces host-protective immune responses

被引：30

作者：

Hartmann, S

Adam, R

Marti, T

Kirsten, C

Seidinger, S

Lucius, R

机构：

[1] BERNHARD NOCHT INST TROP MED,HAMBURG,GERMANY

[2] INST TROP MED & HYG,HEIDELBERG,GERMANY

来源：

PARASITOLOGY RESEARCH | 1997年 / 83卷 / 04期

关键词：

D O I：

10.1007/s004360050269

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

A purified 41-kDa protein of the rodent filaria Acanthocheilonema viteae was shown to protect jirds against a challenge infection. Subcutaneous immunization with the protein reduced the number of adult worms by up to 65% and the number of circulating microfilariae declined by up to 93% in these animals. The protein is located in the muscle tissues of adult worms and was identified as tropomyosin by N-terminal sequencing of the purified protein.

引用

页码：390 / 393

页数：4

共 18 条

[11]

MATSUDAIRA P, 1987, J BIOL CHEM, V262, P10035

[12]

NANDURI J, 1989, J IMMUNOL, V143, P3359

[13] A NOVEL HOST-PROTECTIVE ANTIGEN FROM TRICHOSTRONGYLUS-COLUBRIFORMIS [J].