Efficacy of treatment with chimeric monoclonal antibody (Infliximab) to tumor necrosis factor-α for Crohn's disease in Japan:: Evaluation by rapid turnover proteins, and radiologic and endoscopic findings

被引：16

作者：

Asakura, H

Yao, T

Matsui, T

Koganei, K

Fukushima, T

Takazoe, M

Hobara, R

Nakano, H

Okamura, S

Matsueda, K

Kashida, H

Makiyama, K

Hiwatashi, N

Kashiwagi, K

Hibi, T

机构：

[1] Niigata Univ, Sch Med, Dept Internal Med 3, Niigata 9518122, Japan

[2] Fukuoka Univ, Chikushi Hosp, Dept Gastroenterol, Chikushi, Japan

[3] Yokohama Municipal Citizens Hosp, Dept Surg, Yokohama, Kanagawa, Japan

[4] Social Hlth Insurance Med Ctr, Dept Internal Med, Tokyo, Japan

[5] Fijita Hlth Univ, Sch Med, Dept Internal Med, Nagoya, Aichi, Japan

[6] Toyohashi Municipal Hosp, Dept Gastroenterol, Toyohashi, Aichi, Japan

[7] Int Med Ctr Japan, Div Gastroenterol, Tokyo, Japan

[8] Kobe City Gen Hosp, Div Gastroenterol, Kobe, Hyogo, Japan

[9] Nagasaki Univ, Sch Med, Dept Endoscopy, Nagasaki 852, Japan

[10] Tohoku Univ, Sch Med, Dept Internal Med 3, Sendai, Miyagi 980, Japan

[11] Keio Univ, Dept Internal Med, Tokyo, Japan

[12] Keio Canc Ctr, Keio, Japan

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2001年 / 16卷 / 07期

关键词：

Crohn's disease; Crohn's disease activity index; index of inflammatory bowel disease; monoclonal antibody; rapid turnover proteins; treatment; tumor necrosis factor-alpha;

D O I：

10.1046/j.1440-1746.2001.02507.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Several studies have reported that the chimeric monoclonal antibody to tumor necrosis factor (TNF)-alpha (Infliximab) is extremely valuable in the treatment of Crohn's disease. The aim of this study was to clarify the efficacy of this treatment in Japanese patients with Crohn's disease. Methods: A 12-week multicenter, open trial of Infliximab was carried out and involved 25 patients With moderate to severe Crohn's disease who were resistant to conventional treatment. Patients received a single 2-h intravenous infusion of Infliximab at a dose of 1, 3, 5 or 10 mg/kg bodyweight. Clinical evaluation of this treatment response was defined as a reduction in the index of the inflammatory bowel disease (IOIBD) and of the Crohn's disease activity index scores (CDAI), and in serum levels of C-reactive protein (CRP) at 2, 4, 8 and 12 weeks, and as an increase in serum levels of rapid turnover proteins as well as improvement of radiologic and endoscopic findings at 4 weeks. Results: The IOIBD score was reduced after 4 weeks in 66.7% of the group receiving 1 mg/kg Infliximab, 71.4% in the group receiving 3 mg/kg, 80.0% in the group receiving 5 mg/kg, and 85.7% in the group receiving 10 mg/kg. Improvement was better maintained over 12 weeks in the 5 and 10 mg/kg groups compared with the 1 and 3 mg/kg groups. Similar results were obtained for the CDAI scores. Serum levels of rapid turnover proteins significantly increased to within the normal ranges after infusion in all groups. Seven of the 11 (63.6%) patients evaluated showed improvement of radiologic and endoscopic findings. Conclusions: A single infusion of Infliximab was effective for the treatment of Japanese patients with Crohn's disease. Serum rapid turnover proteins reflected the clinical response to antibody for TNF-alpha well. (C) 2001 Blackwell Science Asia Pty Ltd.

引用

页码：763 / 769

页数：7

共 22 条

[1]

BEST WR, 1979, GASTROENTEROLOGY, V77, P843

[2]

Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial [J].