Non-viral gene delivery carrier and its three-dimensional transfection system

被引：84

作者：

He, Cai-Xia ^{[1
]}

Tabata, Yasuhiko ^{[2
]}

Gao, Jian-Qing ^{[1
]}

机构：

[1] Zhejiang Univ, Inst Pharmaceut, Hangzhou 310058, Zhejiang, Peoples R China

[2] Kyoto Univ, Inst Frontier Med Sci, Field Tissue Engn, Dept Biomat,Sakyo Ku, Kyoto 6068507, Japan

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2010年 / 386卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

Non-viral vector; Gene delivery; Polyplexes; PEI; Lipoplexes; Three-dimensional scaffolds; MESENCHYMAL STEM-CELLS; LOW-MOLECULAR-WEIGHT; TISSUE-ENGINEERING SCAFFOLDS; IN-VIVO; CATIONIC LIPOSOMES; PLASMID DNA; TUMOR-CELLS; MODIFIED POLYETHYLENIMINES; INTRAVENOUS-INJECTION; TRANSGENE EXPRESSION;

D O I：

10.1016/j.ijpharm.2009.11.006

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

An increasing number of non-viral vectors are being developed for the use of gene delivery nowadays, among which cationic polymers and lipoplexes receive most attention. Most of these researches are focused on how to increase the transfection efficiency of non-viral vectors as well as the reduction of toxicity. In this review, we go over new strategies to reduce the toxicity of cationic polyplexes such as poly(ethylene-imine) and the construction of highly effective gene transfer vector lipoplexes. In addition, since transformation of gene expression system from two-dimensional (2D) substrate to 3D scaffold triggers far better transfection efficiency, the non-viral vectors applied in 3D transfection system have also been reviewed. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：232 / 242

页数：11

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