Biocompatibility of corrosion-resistant zeolite coatings for titanium alloy biomedical implants

被引:124
作者
Bedi, Rajwant S. [1 ]
Beving, Derek E. [1 ]
Zanello, Laura P. [2 ]
Yan, Yushan [1 ]
机构
[1] Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA
[2] Univ Calif Riverside, Dept Biochem, Riverside, CA 92521 USA
关键词
Corrosion resistant; Biocompatible; Zeolite; Biomaterial; Stem cells; Y-TYPE ZEOLITES; IN-VITRO; BIOMATERIALS; SILICATES; COMPLEXES; ALUMINUM; RELEASE;
D O I
10.1016/j.actbio.2009.04.019
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Titanium alloy, Ti6Al4V, is widely used in dental and orthopedic implants. Despite its excellent biocompatibility, Ti6Al4V releases toxic Al and V ions into the surrounding tissue after implantation. In addition, the elastic modulus of Ti6Al4V (similar to 110 GPa) is significantly higher than that of bone (10-40 GPa), leading to a modulus mismatch and consequently implant loosening and deosteointegration. Zeolite coatings are proposed to prevent the release of the toxic ions into human tissue and enhance osteointegration by matching the mechanical properties of bone. Zeolite MFI coatings are successfully synthesized on commercially pure titanium and Ti6Al4V for the first time. The coating shows excellent adhesion by incorporating titanium from the substrate within the zeolite framework. Higher corrosion resistance than the bare titanium alloy is observed in 0.856 M NaCl solution at pHs of 7.0 and 1.0. Zeolite coatings eliminate the release of cytotoxic Al and V ions over a 7 day period. Pluripotent mouse embryonic stem cells show higher adhesion and cell proliferation on the three-dimensional zeolite microstructure surface compared with a two-dimensional glass surface, indicating that the zeolite coatings are highly biocompatible. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:3265 / 3271
页数:7
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