Bioactive Constituents of the Stem Bark of Mitrephora glabra

被引：58

作者：

Li, Chen ^{[2
]}

Lee, Dongho ^{[2
]}

Graf, Tyler N. ^{[2
]}

Phifer, Sharnelle S. ^{[2
]}

Nakanishi, Yuka ^{[2
]}

Riswan, Soedarsono ^{[1
]}

Setyowati, Fransisca M. ^{[1
]}

Saribi, Achmad M. ^{[3
]}

Soejarto, Djaja D. ^{[4
,5
]}

Farnsworth, Norman R. ^{[4
,5
]}

Falkinham, Joseph O., III ^{[6
]}

Kroll, David J. ^{[2
]}

Kinghorn, A. Douglas ^{[7
]}

Wani, Mansukh C. ^{[2
]}

Oberlies, Nicholas H. ^{[2
]}

机构：

[1] Indonesian Inst Sci, Herbarium Borgoriense, Res & Dev Ctr Biol, Bogor 16122, Indonesia

[2] Res Triangle Inst, Nat Prod Lab, Res Triangle Pk, NC 27709 USA

[3] Kapuas Regency, Reg Planning & Dev Board BAPPEDA, Cent Kalimantan, Indonesia

[4] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

[5] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

[6] Virginia Polytech Inst & State Univ, Dept Biol, Blacksburg, VA 24061 USA

[7] Ohio State Univ, Coll Pharm, Columbus, OH 43210 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 11期

关键词：

DITERPENES; POLYACETYLENE; ANNONACEAE; DISCOVERY;

D O I：

10.1021/np900572g

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three entkaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.

引用

页码：1949 / 1953

页数：5

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