Structural biology of enzymes involved in NAD and molybdenum cofactor biosynthesis

被引：42

作者：

Rizzi, M

Schindelin, H

机构：

[1] Univ Piemonte Orientale, DISCAFF INFM, I-28100 Novara, Italy

[2] Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy

[3] SUNY Stony Brook, Dept Biochem, Stony Brook, NY 11794 USA

[4] SUNY Stony Brook, Ctr Struct Biol, Stony Brook, NY 11794 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2002年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0959-440X(02)00385-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structural analysis of all enzymes in a metabolic pathway is a prerequisite to answering fascinating questions, such as those relating to the evolutionary relationships between enzymes within the same and related pathways. Furthermore, the observed impressive diversity of catalytic functions displayed by these enzymes can lead to the synthesis of highly complex or unstable molecules, frequently involving unusual chemical reactions. Moreover, a detailed description of the active site of each enzyme in a pathway is of immense importance for the rational design of new drugs. The recent progress made in the structural biology of enzymes involved in NAD and molybdenum cofactor biosynthesis presents a significant step toward these goals.

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收藏

页码：709 / 720

页数：12

相关论文

共 76 条

[51] Genomic structure and mutational spectrum of the bicistronic MOCS1 gene defective in molybdenum cofactor deficiency type A [J].

Reiss, J ;

Christensen, E ;

Kurlemann, G ;

Zabot, MT ;

Dorche, C .

HUMAN GENETICS, 1998, 103 (06) :639-644

[52] Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B [J].

Reiss, J ;

Dorche, C ;

Stallmeyer, B ;

Mendel, RR ;

Cohen, N ;

Zabot, MT .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 64 (03) :706-711

[53] A mutation in the gene for the neurotransmitter receptor-clustering protein gephyrin causes a novel form of molybdenum cofactor deficiency [J].

Reiss, J ;

Gross-Hardt, S ;

Christensen, E ;

Schmidt, P ;

Mendel, RR ;

Schwarz, G .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (01) :208-213

[54] Rearrangement reactions in the biosynthesis of molybdopterin -: An NMR study with multiply 13C/15N labelled precursors [J].

Rieder, C ;

Eisenreich, W ;

O'Brien, J ;

Richter, G ;

Götze, E ;

Boyle, P ;

Blanchard, S ;

Bacher, A ;

Simon, H .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 255 (01) :24-36

[55] Crystal structure of NH3-dependent NAD(+) synthetase from Bacillus subtilis [J].

Rizzi, M ;

Nessi, C ;

Mattevi, A ;

Coda, A ;

Bolognesi, M ;

Galizzi, A .

EMBO JOURNAL, 1996, 15 (19) :5125-5134

[56] A novel deamido-NAD+-binding site revealed by the trapped NAD-adenylate intermediate in the NAD+ synthetase structure [J].

Rizzi, M ;

Bolognesi, M ;

Coda, A .

STRUCTURE, 1998, 6 (09) :1129-1140

[57]

Rudolph MJ, 2001, NAT STRUCT BIOL, V8, P42

[58] Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling [J].

Sabatini, DM ;

Barrow, RK ;

Blackshaw, S ;

Burnett, PE ;

Lai, MM ;

Field, ME ;

Bahr, BA ;

Kirsch, J ;

Betz, H ;

Snyder, SH .

SCIENCE, 1999, 284 (5417) :1161-1164

[59] Insights into ligand binding and catalysis of a central step in NAD+ synthesis -: Structures of Methanobacterium thermoautotrophicum NMN adenylyltransferase complexes [J].

Saridakis, V ;

Christendat, D ;

Kimber, MS ;

Dharamsi, A ;

Edwards, AM ;

Pai, EF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (10) :7225-7232

[60]

Schindelin H, 2001, ADV PROTEIN CHEM, V58, P47

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