Chymase inhibitors and their therapeutic potential

被引：4

作者：

Akahoshi, F ^{[1
]}

机构：

[1] Mitsubishi Pharma Corp, Pharmaceut Res Unit, Res Lab 2, Aoba Ku, Yokohama, Kanagawa 2270033, Japan

来源：

DRUGS OF THE FUTURE | 2002年 / 27卷 / 08期

关键词：

D O I：

10.1358/dof.2002.027.08.688468

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：765 / 770

页数：6

共 56 条

[1] Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic α-keto heterocycles as novel inhibitors of human chymase [J].

Akahoshi, F ;

Ashimori, A ;

Sakashita, H ;

Yoshimura, T ;

Imada, T ;

Nakajima, M ;

Mitsutomi, N ;

Kuwahara, S ;

Ohtsuka, T ;

Fukaya, C ;

Miyazaki, M ;

Nakamura, N .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (08) :1286-1296

[2] Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase [J].

Akahoshi, F ;

Ashimori, A ;

Sakashita, H ;

Yoshimura, T ;

Eda, M ;

Imada, T ;

Nakajima, M ;

Mitsutomi, N ;

Kuwahara, S ;

Ohtsuka, T ;

Fukaya, C ;

Miyazaki, M ;

Nakamura, N .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (08) :1297-1304

[3] Non-peptidic inhibitors of human chymase. Synthesis, structure-activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones [J].

Akahoshi, F ;

Ashimori, A ;

Yoshimura, T ;

Imada, T ;

Nakajima, M ;

Mitsutomi, N ;

Kuwahara, S ;

Ohtsuka, T ;

Fukaya, C ;

Miyazaki, M ;

Nakamura, N .

BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (02) :301-315

[4] 1-Oxacephem-based human chymase inhibitors: Discovery of stable inhibitors in human plasma [J].

Aoyama, Y ;

Uenaka, M ;

Konoike, T ;

Iso, Y ;

Nishitani, Y ;

Kanda, A ;

Naya, N ;

Nakajima, M .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (21) :2403-2406

[5] Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors [J].

Aoyama, Y ;

Uenaka, M ;

Konoike, T ;

Iso, Y ;

Nishitani, Y ;

Kanda, A ;

Naya, N ;

Nakajima, M .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (21) :2397-2401

[6] Total synthesis of human chymase inhibitor methyllinderone and structure-activity relationships of its derivatives [J].

Aoyama, Y ;

Konoike, T ;

Kanda, A ;

Naya, N ;

Nakajima, M .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (13) :1695-1697

[7] Inhibition of serine proteases: Activity of 1,3-diazetidine-2,4-diones [J].

Aoyama, Y ;

Uenaka, M ;

Konoike, T ;

Hayasaki-Kajiwara, Y ;

Naya, N ;

Nakajima, M .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (13) :1691-1694

[8] Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors [J].

Aoyama, Y ;

Uenaka, M ;

Kii, M ;

Tanaka, M ;

Konoike, T ;

Hayasaki-Kajiwara, Y ;

Naya, N ;

Nakajima, M .

BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (11) :3065-3075

[9] INHIBITORS OF HUMAN HEART CHYMASE BASED ON A PEPTIDE LIBRARY [J].

BASTOS, M ;

MAEJI, NJ ;

ABELES, RH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (15) :6738-6742

[10] Purification and characterization of interleukin 1β from human plantar stratum corneum.: Evidence of interleukin 1β processing in vivo not involving interleukin 1β convertase [J].

Brattsand, M ;

Egelrud, T .

CYTOKINE, 1998, 10 (07) :506-513

← 1 2 3 4 5 6 →