Facile synthesis of steroidal phenyl ketones via homogeneous catalytic carbonylation

被引：34

作者：

Skoda-Földes, R

Székvölgyi, Z

Kollár, L

Berente, Z

Horváth, J

Tuba, Z

机构：

[1] Univ Veszprem, Hungarian Acad Sci, Dept Organ Chem, H-8200 Veszprem, Hungary

[2] Univ Veszprem, Res Grp Petrochem, H-8200 Veszprem, Hungary

[3] Janus Pannonius Univ, Dept Inorgan Chem, H-7624 Pecs, Hungary

[4] Hungarian Acad Sci, Res Grp Chem Sensors, H-7624 Pecs, Hungary

[5] Univ Pecs, Sch Med, Dept Biochem, H-7623 Pecs, Hungary

[6] Chem Works Gedeon Richter Ltd, Budapest, Hungary

来源：

TETRAHEDRON | 2000年 / 56卷 / 21期

基金：

匈牙利科学研究基金会;

关键词：

Pd-catalysis; carbonylation; phenyl ketones; steroids;

D O I：

10.1016/S0040-4020(00)00241-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Steroidal phenyl ketones were synthesised in high yields by palladium-catalysed carbonylation reactions of 17-iodo-androst-16-ene derivatives in the presence of NaBPh4 under mild reaction conditions. Alkenyl bromides or enol triflates gave lower yields in the same reaction. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3415 / 3418

页数：4

共 18 条

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Alper H., 1979, TETRAHEDRON LETT, V20, P2665

[2] BETA-ARYL AND BETA-VINYL-ALPHA,BETA-DIDEHYDRO-ALPHA-AMINOACID DERIVATIVES THROUGH THE PALLADIUM-CATALYZED REACTION OF ARYL AND VINYL TRIFLATES WITH METHYL ALPHA-ACETAMIDOACRYLATE [J].