A novel surface-induced dissociation instrument for ion mobility-time-of-flight mass spectrometry

被引：23

作者：

Sun, Wenjian ^{[1
]}

May, Jody C. ^{[1
]}

Russell, David H. ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, Lab Biol Mass Spectrometry, College Stn, TX 77843 USA

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2007年 / 259卷 / 1-3期

关键词：

matrix assisted laser desorption/ionization; surface-induced dissociation; ion mobility; time-of-flight;

D O I：

10.1016/j.ijms.2006.09.005

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

A surface-normal surface-induced dissociation (SID) configuration specifically designed for coupling ion mobility spectrometry (IMS) and orthogonal time-of-flight (TOF) mass spectrometer is described. The instrument configuration and the effects of various operating parameters are critically evaluated using ion trajectory calculations (SIMION) and SID spectra of a series of model peptides. The utility of the instrument configuration for simultaneous acquisition of MS and MS-MS spectra in both data-dependent and non-data-dependent modes are also discussed. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：79 / 86

页数：8