The Discovery of Cellular Immunity in the Atherosclerotic Plaque

被引：126

作者：

Hansson, Goran K.

Jonasson, Lena

机构：

[1] Karolinska Univ Hosp, Karolinska Inst, Dept Med, Stockholm, Sweden

[2] Karolinska Univ Hosp, Ctr Mol Med, Stockholm, Sweden

[3] Linkoping Univ, Dept Med & Hlth Sci, Div Cardiovasc Med, S-58183 Linkoping, Sweden

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2009年 / 29卷 / 11期

基金：

瑞典研究理事会;

关键词：

athersclerosis; immunity; inflammation; cytokines; T cells; macrophages; SMOOTH-MUSCLE CELLS; LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; T-CELLS; AGGRAVATES ATHEROSCLEROSIS; IA ANTIGENS; HLA-DR; HYPERCHOLESTEROLEMIC MICE; EXPRESSION; LYMPHOCYTES;

D O I：

10.1161/ATVBAHA.108.179713

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

It is now generally accepted that atherosclerosis is an inflammatory/immune disease triggered by LDL accumulation in the artery wall. When discovering T cells and the molecular components of a cellular immune response, we proposed that atherosclerosis is an inflammatory process with an autoimmune component. This notion was met with general skepticism but has gained support from experimental and clinical studies. Here we describe some of the early studies that helped developing this concept. (Arterioscler Thromb Vasc Biol. 2009; 29: 1714-1717.)

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页码：1714 / 1717

页数：4

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