Cellular copper management-a draft user's guide

被引:56
作者
Bertini, Ivano [1 ,2 ]
Cavallaro, Gabriele [1 ]
McGreevy, Kathleen S. [1 ]
机构
[1] Univ Florence, Magnet Resonance Ctr CERM, I-50019 Sesto Fiorentino, Italy
[2] Univ Florence, Dept Chem, I-50019 Sesto Fiorentino, Italy
关键词
Copper; Copper homeostasis; Copper site; Copper protein; Protein structure; CYTOCHROME-C-OXIDASE; AMYLOID PRECURSOR PROTEIN; CRYSTAL-STRUCTURE; ALZHEIMERS-DISEASE; MOLECULAR-MECHANISMS; ESCHERICHIA-COLI; BINDING; METAL; METALLOCHAPERONE; HOMEOSTASIS;
D O I
10.1016/j.ccr.2009.07.024
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Copper is essential to many organisms as a cofactor for many proteins and enzymes involved in key biological processes such as respiration and protection from oxidative stress. However, as copper is potentially toxic to living systems, regulatory mechanisms have evolved for its acquisition, trafficking, and release. These mechanisms, whose malfunction is typically associated with severe cellular damage, rely on the concerted action of protein systems that implement mechanisms for copper homeostasis and usage. The ensemble of copper proteins in given organisms can now be predicted with bioinformatics methods from an analysis of amino acid sequences. This work has endeavored to study the copper binding sites in these proteins, and to classify them based on their structural features. When associated with information on occurrence throughout the domains of life and intracellular localization, some generalized perspectives on copper management emerge that may provide a basis for the creation of models of cellular copper metabolism within a systems framework. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:506 / 524
页数:19
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