Is pathogenic humoral autoimmunity a Th1 response? Lessons from (for) myasthenia gravis

被引：36

作者：

Balasa, B ^{[1
]}

Sarvetnick, N ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 01期

关键词：

D O I：

10.1016/S0167-5699(99)01553-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Myasthenia gravis (MG) is mediated by autoantibodies to the nicotinic acetylcholine receptor (AChR). Although AChR-specific T cells are necessary for disease development, the role of cytokines is not clear. Here, Balaji Balasa and Nora Sarvetnick discuss the T helper 1 (Th1)/Th2 paradigm and emerging evidence that interferon gamma (IFN-gamma) and interleukin 12 (IL-12) are important in experimental autoimmune MG pathogenesis.

引用

页码：19 / 23

页数：5

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