Characteristics of community- and hospital-acquired meticillin-resistant Staphylococcus aureus strains carrying SCCmec type IV isolated in Malaysia

被引：48

作者：

Ahmad, Norazah ^{[1
]}

Ruzan, Izayu Nurfarha ^{[1
]}

Abd Ghani, Mohamed Kamel ^{[2
]}

Hussin, Azura ^{[3
]}

Nawi, Salbiah ^{[4
]}

Aziz, Mohamad Nazri ^{[5
]}

Maning, Nurahan ^{[6
]}

Eow, Victor Lim Kok ^{[7
]}

机构：

[1] Inst Med Res, Kuala Lumpur 50588, Malaysia

[2] Univ Kebangsaan Malaysia, Dept Biomed Sci, Kuala Lumpur, Malaysia

[3] Queen Elizabeth Hosp, Dept Microbiol, Sabah, Malaysia

[4] Selayang Hosp, Dept Microbiol, Selangor, Malaysia

[5] Kuala Lumpur Hosp, Dept Microbiol, Kuala Lumpur, Malaysia

[6] Kota Bharu Hosp, Dept Microbiol, Kelantan, Malaysia

[7] Int Med Univ, Kuala Lumpur 57000, Malaysia

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 2009年 / 58卷 / 09期

基金：

美国国家卫生研究院;

关键词：

CASSETTE CHROMOSOME MEC; VALENTINE LEUKOCIDIN GENES; METHICILLIN-RESISTANT; CLONES; SPREAD; MRSA; SUSCEPTIBILITY; PREDOMINANCE; INFECTIONS; EMERGENCE;

D O I：

10.1099/jmm.0.011353-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) occurring among hospital isolates in Malaysia has not been reported previously. As CA-MRSA reported worldwide has been shown to carry SCCmec types IV and V, the aim of this study was to determine the SCCmec types of MRSA strains collected in Malaysia from November 2006 to June 2008. From a total of 628 MRSA isolates, 20 were SCCmec type IV, whilst the rest were type III. Further characterization of SCCmec type IV strains revealed 11 sequence types (STs), including ST22, with the majority being ST30/Panton-Valentine leukocidin positive. Eight out of nine CA-MRSA were ST30, one was ST80, and all were sensitive to co-trimoxazole and gentamicin. Five new STs designated ST1284, ST1285, ST1286, ST1287 and ST1288 were discovered, suggesting the emergence of novel clones of MRSA circulating in Malaysian hospitals. The discovery of the ST22 strain is a cause for concern because of its ability to replace existing predominant clones in certain geographical regions.

引用

页码：1213 / 1218

页数：6

共 36 条

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