Neuronal fast oscillations as a target site for psychoactive drugs

被引:110
作者
Whittington, MA
Faulkner, HJ
Doheny, HC
Traub, RD
机构
[1] Univ Leeds, Sch Biomed Sci, Leeds LS2 9NL, W Yorkshire, England
[2] Univ Birmingham, Sch Med, Div Neurosci, Birmingham B15 2TT, W Midlands, England
基金
英国惠康基金;
关键词
gamma oscillation; beta oscillation; anaesthesia; hallucinations; schizophrenia;
D O I
10.1016/S0163-7258(00)00038-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Neuronal oscillations within the electroencephalogram beta and gamma bands (15-80 Hz) are associated with intense mental activity and cognitive function in general. Specifically, recent advances have implicated gamma oscillations in the processing of sensory stimuli and demonstrated that synchronous gamma oscillations, appearing concurrently in spatially separate brain regions, can induce beta activity. beta activity generated in this manner represents established synchronous communication between brain regions and is thought to represent a neuronal network correlate of the "binding phenomenon" in cognitive theory. This review will outline the mechanisms of generation of these oscillations at the cellular and network level, and will highlight the effects of drugs that may modify these mechanisms. Possible modification of fast oscillations by disease processes and clinical intervention are discussed. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:171 / 190
页数:20
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