In situ iodination and X-ray crystal structure of a foldamer helix bundle

被引：12

作者：

Collie, Gavin William ^{[1
]}

Pulka-Ziach, Karolina ^{[1
]}

Guichard, Gilles ^{[1
]}

机构：

[1] Univ Bordeaux, CNRS, UMR 5248, CBMN,Inst Europeen Chim & Biol, F-33607 Pessac, France

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 06期

关键词：

PEPTIDE; OLIGOMERS; SEQUENCE; DESIGN; CORE;

D O I：

10.1039/c5cc07916k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report here the efficient in situ iodination of tyrosine-type side-chains located within a foldamer helix bundle, permitting structure determination using single-wavelength anomalous diffraction (SAD) methods. We suggest that this simple method may be of use to those engaged in structural foldamer research as a potential solution to the phase problem.

引用

页码：1202 / 1205

页数：4

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