Immunostimulatory activity of CpG containing phosphorothioate oligodeoxynucleotide is modulated by modification of a single deoxynucleoside

被引：49

作者：

Zhao, QY ^{[1
]}

Yu, D ^{[1
]}

Agrawal, S ^{[1
]}

机构：

[1] Hybridon Inc, Milford, MA 01757 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(00)00157-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phosphorothioate oligodeoxynucleotides (PS-oligos) containing the CpG motif have immunostimulatory properties. Our earlier study had shown that the immunostimulatory activity of PS-oligos containing the CpG motif can be modulated by incorporation of 2'-O-methylribonucleosides (Zhao, Q.; Yu, D.; Agrawal, S. Bioorg. Med. Chem. Lett. 1999, 9, 3453). Here we show that the immunostimulatory activity of a PS-oligo containing a CpG motif can be modulated by substitution of a single deoxynucleoside at specific sites with either 2'-O-methylribonucleoside or 3'-O-methylribonucleoside in the flanking region to CpG motif. Furthermore, substitution of deoxynucleosides with 2'-O-methoxyethoxyribonucleosides also results in modulating immunostimulatory activity of PS-oligos. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1051 / 1054

页数：4

共 15 条

[1] Antisense therapeutics [J].