Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER

被引：181

作者：

Chinnapen, Daniel J. -F.

Chinnapen, Himani

Saslowsky, David

Lencer, Wayne I.

机构：

[1] Harvard Univ, Childrens Hosp Boston, Ctr Digest Dis, GI Cell Biol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[3] Harvard Univ, Ctr Digest Dis, Boston, MA 02115 USA

来源：

FEMS MICROBIOLOGY LETTERS | 2007年 / 266卷 / 02期

关键词：

cholera toxin; lipid raft; retrograde pathway; GM1; AB(5) toxin; endocytosis;

D O I：

10.1111/j.1574-6968.2006.00545.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cholera toxin (CT), and members of the AB(5) family of toxins enter host cells and hijack the cell's endogenous pathways to induce toxicity. CT binds to a lipid receptor on the plasma membrane (PM), ganglioside GM1, which has the ability to associate with lipid rafts. The toxin can then enter the cell by various modes of receptor-mediated endocytosis and traffic in a retrograde manner from the PM to the Golgi and the endoplasmic reticulum (ER). Once in the ER, a portion of the toxin is unfolded and retro-translocated to the cytosol so as to induce disease. GM1 is the vehicle that carries CT from PM to ER. Thus, the toxin pathway from PM to ER is a lipid-based sorting pathway, which is potentially meditated by the determinants of the GM1 ganglioside structure itself.

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收藏

页码：129 / 137

页数：9

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