Polymorphisms in Telomere Maintenance Genes and Risk of Lung Cancer

被引：58

作者：

Choi, Jin Eun ^{[2
]}

Kang, Hyo-Gyoung ^{[4
]}

Jang, Jin Sung ^{[2
]}

Choi, Yi Young ^{[2
]}

Kim, Min Jung ^{[2
]}

Kim, Jong Sik ^{[2
]}

Jeon, Hyo-Sung ^{[2
,4
]}

Lee, Won Kee ^{[3
]}

Cha, Sung Ick ^{[1
]}

Kim, Chang Ho ^{[1
]}

Kam, Sin ^{[3
]}

Jung, Tae Hoon ^{[1
]}

Park, Jae Yong ^{[1
,2
,4
]}

机构：

[1] Kyungpook Natl Univ Hosp, Dept Internal Med, Taegu 700412, South Korea

[2] Kyungpook Natl Univ, Sch Med, Dept Biochem, Taegu, South Korea

[3] Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Taegu, South Korea

[4] Daegu & Kyungpook Canc Ctr, Taegu, South Korea

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2009年 / 18卷 / 10期

关键词：

GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCUS; CIGARETTE-SMOKING; PROTEIN COMPLEX; LENGTH; PROMOTER; DYSFUNCTION; ETIOLOGY; CLONING; CELLS;

D O I：

10.1158/1055-9965.EPI-09-0323

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

This study was conducted to comprehensively evaluate the associations between polymorphisms in telomere maintenance genes (TERT, TRF1, TNKS1, TRF2, RAP1, and POT1) and lung cancer risk. We captured 35 polymorphisms in the genes and determined their frequencies in 27 healthy Koreans. Ten haplotype-tagging polymorphisms were examined in a case-control study that consisted of 720 lung cancer patients and 720 healthy controls. The TERTrs2735940 g.C > T and rs2736098 g.G > A, and TNKS1. rs6985140 g.A > G were significantly associated with the risk of lung cancer. In the haplotype analysis, the TERT rs2735940T/rs2736098A haplotype (ht4) was associated with a significantly increased risk of lung cancer compared with the rs2735940C/rs2736098G haplotype (adjusted odds ratio, 1.26; 95% confidence interval, 1.07-1.50; P = 0.008). When the TERT ht4 and TNKS1 rs6985140G as risk alleles, the risk of lung cancer increased in a dose-dependent manner as the number of risk alleles increased (P-trend < 0.001). Subjects with two to four risk alleles were at a significantly increased risk of lung cancer (adjusted odds ratio, 1.67; 95% confidence interval, 1.23-2.27; P = 0.001) compared with subjects with zero risk allele. These findings suggest that genetic variants in the TERT and TNKS1 genes contribute to genetic susceptibility to lung cancer. (Cancer Epidemiol Biomarkers Prev 20091-18(10):2773-81)

引用

页码：2773 / 2781

页数：9

共 40 条

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