Atopic and nonatopic IgE-mediated allergy: A new interpretation of old facts?

被引:3
作者
de Weck, AL [1 ]
机构
[1] Gerimmun Fdn, Fribourg, Switzerland
关键词
atopy; non atopic allergy; IgE; allergic breakthrough; allergy prevention; high IgE responders; low IgE responders;
D O I
10.1159/000065874
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Coined 80 years ago, the term 'atopy' to designate a group of diseases associated with IgE and a hereditary background has raised many discussions. In particular, it is difficult to consider as part of an atopic syndrome cases of IgE-mediated allergies to isolated allergens without evidence of a familial inheritance. The postulate expressed in this essay is that in humans we are essentially dealing with an atopic IgE-mediated allergy, which is the equivalent of a genetically determined high IgE response, and with a nonatopic IgE-mediated allergy, which is the equivalent of a low IgE response in mammals and rodents. Copyright (C) 2002 S. Karger AG, Basel.
引用
收藏
页码:97 / 107
页数:11
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