Cutting edge: Antibody-mediated TLR7-dependent recognition of viral RNA

被引：69

作者：

Wang, Jennifer P. ^{[1
]}

Asher, Damon R. ^{[1
]}

Chan, Melvin ^{[1
]}

Kurt-Jones, Evelyn A. ^{[1
]}

Finberg, Robert W. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Med, Worcester, MA 01605 USA

来源：

JOURNAL OF IMMUNOLOGY | 2007年 / 178卷 / 06期

关键词：

D O I：

10.4049/jimmunol.178.6.3363

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

TLR7 recognizes the genome of ssRNA viruses such as Coxsackievirus B. Because TLR7 is expressed in intracellular compartments, viral RNA must be internalized before its recognition by TLR7. In this study, we define plasmacytoid dendritic cells (pDC) as peripheral blood mononuclear immune cells that respond to Coxsackievirus. pDC activation by Coxsackievirus B requires the presence of specific antiviral Abs. We show that Fc receptors mediate the recognition of virus Ab complexes and that TLR7 is required for human and murine pDC production of eytokines. These data define a pathway by which intracellular TLR7 senses viral RNA and indicate a role for TLRs in association with Abs in sustaining virus-specific responses.

引用

页码：3363 / 3367

页数：5

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