Gombapyrones, new α-pyrone metabolites produced by Streptomyces griseoruber Acta 3662

被引：15

作者：

Helaly, Soleiman ^{[2
]}

Schneider, Kathrin ^{[2
]}

Nachtigall, Jonny ^{[2
]}

Vikineswary, Sabaratnam ^{[3
]}

Tan, Geok Yuan Annie ^{[3
]}

Zinecker, Heidi ^{[4
]}

Imhoff, Johannes F. ^{[4
]}

Suessmuth, Roderich D. ^{[2
]}

Fiedler, Hans-Peter ^{[1
]}

机构：

[1] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

[2] Tech Univ Berlin, Inst Chem, Berlin, Germany

[3] Univ Malaya, Inst Biol Sci, Kuala Lumpur, Malaysia

[4] Leibniz Inst Meereswissensch IFM GEOMAR, Kiel, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2009年 / 62卷 / 08期

关键词：

fermentation; isolation; alpha-pyrone; protein-tyrosine phosphatase inhibitor; Streptomyces; structure elucidation; 2-PYRONES; ASSAY;

D O I：

10.1038/ja.2009.70

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Gombapyrones A-D, new members of the a-pyrone family of secondary metabolites, were produced by Streptomyces griseoruber Acta 3662, which was isolated from bamboo tree rhizosphere. The strain was characterized by its morphological and chemotaxonomical features and by 16S rDNA sequencing as S. griseobuber. The gombapyrone structures were determined by mass spectrometry and by NMR experiments, and were found to have an inhibitory activity against protein tyrosine phosphatase 1B and glycogen synthase kinase 3 beta. The Journal Antibiotics (2009) 62, 445-452; doi:10.1038/ja.2009.70; published online 31 July 2009

引用

页码：445 / 452

页数：8

共 28 条

[1] A high throughput luminescent assay for glycogen synthase kinase-3β inhibitors [J].