Eleven new 2-pyrones from a Fungi Imperfecti, Trichurus terrophilus, found in a screening study guided by immunomodulatory activity

被引：8

作者：

Fujimoto, H ^{[1
]}

Okamoto, Y ^{[1
]}

Sone, E ^{[1
]}

Maeda, S ^{[1
]}

Akiyama, K ^{[1
]}

Ishibashi, M ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 08期

关键词：

immunosuppressive fungal constituent; Trichurus terrophilus; Fungi Imperfecti; 2-pyrone; trichurusin; structure-activity relationship;

D O I：

10.1248/cpb.53.923

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In a screening study on immunomodulatory fungal constituents, eleven new 2-pyrones tentatively named TT 1 (1), and TT 2-11 (2-11) have been isolated from a Fungi Imperfecti, Trichurus terrophilus, and designated rasfonin (1), and trichurusin B-K (2-11), respectively. Compounds 1-4 exhibited considerably high immunosuppressive activities, and compounds 8-11 have shown moderate ones. The structure-activity relationships of these constituents have also been discussed.

引用

页码：923 / 929

页数：7

共 7 条

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Ishibashi, M .

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[3] Six immunosuppressive features from an Ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory activity [J].

Fujimoto, H ;

Nakamura, E ;

Okuyama, E ;

Ishibashi, M .

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[4]

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[7]

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