Six immunosuppressive features from an Ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory activity

被引：91

作者：

Fujimoto, H ^{[1
]}

Nakamura, E ^{[1
]}

Okuyama, E ^{[1
]}

Ishibashi, M ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 08期

关键词：

immunosuppressive fungal metabolite; Zopfiella longicaudata; Ascomycete; anthraquinone; ergostane; structure-activity relationship;

D O I：

10.1248/cpb.52.1005

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In a screening study on immunomodulatory fungal metabolites, three known anthraquinones, carviolin (roseo-purpurin) (1), 1-O-methylemodin (2), omega-hydroxyemodin (citreorosein) (4), and a new anthraquinone, omega-acetylcarviolin (3), together with a known steroid, ergosta-4,6,8(14),22-tetraen-3-one (5) and a new steroid, 25-hydroxyergosta-4,6,8(14),22-tetraen-3-one (6) were isolated from an Ascomycete, Zopfiella longicaudata, and found to have moderate immunosuppressive activities. The structure-activity relationships of these metabolites are discussed.

引用

页码：1005 / 1008

页数：4

共 25 条

[1] Studies in the biochemistry of micro-organisms 64. Emodic acid (4 : 5 : 7-trihydroxyanthraquincine-2-carboxylic acid) and w-hydroxyemod in (4 : 5 : 7-trihydroxy-2-(Hydoxymethyl)-anthraquinone), metabolic products of a strain of Penicillium cyclopium westling [J].

Anslow, WK ;

Breen, J ;

Raistrick, H .

BIOCHEMICAL JOURNAL, 1940, 34 (02) :159-168

[2] ANTHRAQUINONES AND A 10-HYDROXYANTHRONE FROM PHIALOPHORA-ALBA [J].

AYER, WA ;

TRIFONOV, LS .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (02) :317-319

[3] SYNTHESIS OF EMODIN METHYL ETHERS [J].

CAMERON, DW ;

CROSSLEY, MJ .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1977, 30 (05) :1161-1165

[4]

FUJIMOTO H, 1994, CHEM PHARM BULL, V42, P694, DOI 10.1248/cpb.42.694

[5] Immunomodulatory constituents from an ascomycete, Chaetomium seminudum [J].

Fujimoto, H ;

Sumino, M ;

Okuyama, E ;

Ishibashi, M .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (01) :98-102

[6]

Fujimoto H, 1998, CHEM PHARM BULL, V46, P423

[7]

Fujimoto H, 1999, CHEM PHARM BULL, V47, P71

[8] ISOLATION OF SOME IMMUNOSUPPRESSIVE COMPONENTS FROM AN ASCOMYCETE, GELASINOSPORA MULTIFORIS [J].

FUJIMOTO, H ;

SATOH, Y ;

NAKAYAMA, M ;

TAKAYAMA, T ;

YAMAZAKI, M .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1995, 43 (04) :547-552

[9]

Fujimoto H, 1998, CHEM PHARM BULL, V46, P211

[10]

Fujimoto H, 2000, CHEM PHARM BULL, V48, P1436, DOI 10.1248/cpb.48.1436

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