Neuraminidase expressed by Streptococcus pneumoniae desialylates the lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae:: a paradigm for interbacterial competition among pathogens of the human respiratory tract

被引：83

作者：

Shakhnovich, EA ^{[1
]}

King, SJ ^{[1
]}

Weiser, JN ^{[1
]}

机构：

[1] Univ Penn, Dept Microbiol, Sch Med, Philadelphia, PA 19104 USA

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 12期

关键词：

D O I：

10.1128/IAI.70.12.7161-7164.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Both Neisseria meningitidis and Haemophilus influenzae are capable of mimicking host structures by decorating their lipopolysaccharides with sialic acid. We show that a neuraminidase expressed by Streptococcus pneumoniae (NanA) is able to desialylate the cell surfaces of both these species, which reside in and possibly compete for the same host niche.

引用

页码：7161 / 7164

页数：4

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