Immunoglobulin class switching

被引：271

作者：

Stavnezer, J

机构：

[1] Dept. Molec. Genet. and Microbiol., Univ. of Massachusetts Med. School, Worcester

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(96)80058-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibody class switching is induced by B-cell activators in the presence of cytokines. The identity of the heavy-chain class to which a B cell is switched is regulated by cytokines and B-cell activators at the level of transcription of unrearranged heavy chain constant genes. Gene-targeting experiments in mice have proved the essential role of these transcripts in switch recombination. Their possible functions are discussed in the context of a model for the mechanisms of class switching.

引用

页码：199 / 205

页数：7

共 71 条

[51] INDUCTION OF GERM-LINE IMMUNOGLOBULIN HEAVY-CHAIN TRANSCRIPTS BY MITOGENS AND INTERLEUKINS PRIOR TO SWITCH RECOMBINATION [J].