Lipid phase fatty acid flip-flop, is it fast enough for cellular transport?

被引：46

作者：

Kleinfeld, AM ^{[1
]}

机构：

[1] Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA

来源：

JOURNAL OF MEMBRANE BIOLOGY | 2000年 / 175卷 / 02期

关键词：

D O I：

10.1007/s002320001056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism by which fatty acids are transported across cell membranes is controversial. The essence of the controversy is whether transport requires membrane protein mediation or whether the membrane's lipid phase provides a pathway so rapid that a protein is not needed, This review focuses on the mechanisms of fatty acid transport across lipid bilayer membranes. These results for lipid membranes are used to help evaluate transport across cell membranes. Within the context of this analysis, a lipid phase mediated process is consistent with results for the transport of fatty acids across erythrocytes but provides a less adequate explanation for fatty acid transport across more complex cells.

引用

页码：79 / 86

页数：8

共 59 条

[1]

Abumrad N, 1998, J LIPID RES, V39, P2309

[2]

ABUMRAD NA, 1993, J BIOL CHEM, V268, P17665

[3]

ABUMRAD NA, 1981, J BIOL CHEM, V256, P9183

[4] MEMBRANE PARTITION OF FATTY-ACIDS AND INHIBITION OF T-CELL FUNCTION [J].

ANEL, A ;

RICHIERI, GV ;

KLEINFELD, AM .

BIOCHEMISTRY, 1993, 32 (02) :530-536

[5] Mechanisms of cellular uptake of long chain free fatty acids [J].

Berk, PD ;

Stump, DD .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 1999, 192 (1-2) :17-31

[6] PLASMA-MEMBRANE FATTY ACID-BINDING PROTEIN AND MITOCHONDRIAL GLUTAMIC-OXALOACETIC TRANSAMINASE OF RAT-LIVER ARE RELATED [J].

BERK, PD ;

WADA, H ;

HORIO, Y ;

POTTER, BJ ;

SORRENTINO, D ;

ZHOU, SL ;

ISOLA, LM ;

STUMP, D ;

KIANG, CL ;

THUNG, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (09) :3484-3488

[7] Specificities of red cell membrane sites transporting three long chain fatty acids [J].

Bojesen, IN ;

Bojesen, E .

JOURNAL OF MEMBRANE BIOLOGY, 1996, 149 (03) :257-267

[8] TRANSLOCATION OF OLEIC-ACID ACROSS THE ERYTHROCYTE-MEMBRANE - EVIDENCE FOR A FAST PROCESS [J].

BRORING, K ;

HAEST, CWM ;

DEUTICKE, B .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 986 (02) :321-331

[9] IS THERE FACILITATED UPTAKE OF FATTY-ACIDS BY THE LIVER INTERPRETATION AND ANALYSIS OF EXPERIMENTAL-DATA [J].

BURCZYNSKI, FJ ;

LUXON, BA .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1995, 73 (04) :409-420

[10] Intracellular pH in adipocytes: Effects of free fatty acid diffusion across the plasma membrane, lipolytic agonists, and insulin [J].

Civelek, VN ;

Hamilton, JA ;

Tornheim, K ;

Kelly, KL ;

Corkey, BE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) :10139-10144

← 1 2 3 4 5 6 →