Lipid phase fatty acid flip-flop, is it fast enough for cellular transport?

被引：46

作者：

Kleinfeld, AM ^{[1
]}

机构：

[1] Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA

来源：

JOURNAL OF MEMBRANE BIOLOGY | 2000年 / 175卷 / 02期

关键词：

D O I：

10.1007/s002320001056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism by which fatty acids are transported across cell membranes is controversial. The essence of the controversy is whether transport requires membrane protein mediation or whether the membrane's lipid phase provides a pathway so rapid that a protein is not needed, This review focuses on the mechanisms of fatty acid transport across lipid bilayer membranes. These results for lipid membranes are used to help evaluate transport across cell membranes. Within the context of this analysis, a lipid phase mediated process is consistent with results for the transport of fatty acids across erythrocytes but provides a less adequate explanation for fatty acid transport across more complex cells.

引用

页码：79 / 86

页数：8

共 59 条

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