Palladium-catalyzed α-arylation of N-protected 2-piperidinones

被引:21
作者
de Filippis, A [1 ]
Pardo, DG [1 ]
Cossy, J [1 ]
机构
[1] ESPCI, CNRS, Lab Chim Organ Assoc, F-75231 Paris 05, France
关键词
arylations lactams; palladium; zinc; coupling;
D O I
10.1016/j.tet.2004.06.152
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A very simple method for obtaining alpha-arylated N-protected 2-piperidinones in high yield is described. The use of ZnCl2 and Pd(dba)(2) and the nature of the base are the key factors. (C) 2004 Elsevier Ltd. All rights reserved.
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页码:9757 / 9767
页数:11
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